Comparative analysis of Circulating Tumour Cells detection and circulating tumor DNA in liquid biopsy for the diagnosis of early stage pancreatic adenocarcinoma

Background: Pancreatic ductal adenocarcinoma (PDAC) survival can reach 20% when surgery is possible, giving the best chance to the patients. If patients present locally advance disease, it is crucial to quickly establish resectability to avoid unneeded and even deleterious surgery in patients with metastatic disease. It is also important to increase the rate of true R0 resection with neoadjuvant therapy. However, when the cancer is suspected,...