Pathogenic effector TH2 lymphocytes in human nasal polyposis

Pathogenic effector TH2 (peTH2, also referred to as TH2A) cells represent a T lymphocyte subset increased in allergic disease. peTH2 cells express hematopoietic prostaglandin D synthase (hPGDS) and produce prostaglandin D2 (PGD2). They also express the PGD2 receptor, chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2), and the lipid mediator-responsive transcription factor peroxisome proliferator-activated receptor γ...