Spray-dried nanoparticle-loaded pectin microspheres for dexamethasone nasal delivery

In this study, we present the development of an innovative dry powder dexamethasone (Dex) nasal delivery system comprising Dex-loaded lipid/alginate nanoparticles incorporated within pectin microspheres (Dex/NPs-loaded pectin microspheres; DNM). DNM microspheres were characterized by the mean diameter of 2.76 ± 0.10 µm, zeta-potential of –36.2 ± 1.1 mV, and drug loading of 3.3 ± 0.3%. The morphology study revealed irregular microsphere surface...