Original paper
Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells
Abstract
Cell-identity switches, in which terminally differentiated cells are converted into different cell types when stressed, represent a widespread regenerative strategy in animals, yet they are poorly documented in mammals. In mice, some glucagon-producing pancreatic α-cells and somatostatin-producing δ-cells become insulin-expressing cells after the ablation of insulin-secreting β-cells, thus promoting diabetes recovery. Whether human islets also...
Paper Details
Title
Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells
Published Date
Feb 13, 2019
Journal
Volume
567
Issue
7746
Pages
43 - 48
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Notes
History