Regulation of globin-heme balance in Diamond-Blackfan anemia by HSP70/GATA1
Abstract
Diamond-Blackfan anemia (DBA) is a congenital erythroblastopenia that is characterized by a blockade in erythroid differentiation related to impaired ribosome biogenesis. DBA phenotype and genotype are highly heterogeneous. We have previously identified 2 in vitro erythroid cell growth phenotypes for primary CD34+ cells from DBA patients and following short hairpin RNA knockdown of RPS19, RPL5, and RPL11 expression in normal human CD34+ cells....
Paper Details
Title
Regulation of globin-heme balance in Diamond-Blackfan anemia by HSP70/GATA1
Published Date
Mar 21, 2019
Journal
Volume
133
Issue
12
Pages
1358 - 1370
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History