Specific IgG4 to milk proteins during oral immunotherapy for milk allergy: relationship to eosinophilic esophagitis

During milk oral immunotherapy (OIT), IgG4 levels to cow's milk (CM) increase and may have a protective effect on IgE-mediated responses. On the other hand, elevated levels of milk-specific IgG4 might be related to eosinophilic esophagitis (EoE). We evaluated milk allergic patients during milk OIT (baseline and end of treatment) with specific IgE and IgG4 to milk, α-lactalbumin, β-lactoglobulin, caseins and wheat using commercially available...