Association of FMO3 Variants with Blood Pressure in the Atherosclerosis Risk in Communities Study

Flavin containing monooxygenase 3 [ FMO3 ] encodes dimethylaniline monooxygenase [N-oxide-forming] 3, which breaks down nitrogen-containing compounds, and has been implicated in blood pressure regulation. Studies have reported conflicting results of the association of a common nonsynonymous variant, E158K (rs2266782), with hypertension. We examined the associations of E158K, along with rare and low frequency exonic variants (minor allele...