Open Chromatin, Epigenetic Plasticity, and Nuclear Organization in Pluripotency
Abstract
Pluripotent embryonic stem cells (ESCs) are considered to have open and accessible chromatin relative to differentiated cells. However, as many studies supporting these conclusions relied on ESCs grown in serum, it has been suggested that some of these features are the result of culture conditions, particularly as more recent work using GSK3/MEK inhibitors (2i) to mimic ground-state conditions of the pre-implantation blastocyst observed some...
Paper Details
Title
Open Chromatin, Epigenetic Plasticity, and Nuclear Organization in Pluripotency
Published Date
Jan 28, 2019
Journal
Volume
48
Issue
2
Pages
135 - 150
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