The Role of GSK3B Mislocalization in Arrythmogenic Cardiomyopathy

Arrythmogenic cardiomyopathy (ACM) is a genetic cardiomyopathy commonly inherited through dominant mutations in desmosomal genes (JUP, DSP, PKP2, DSG2, and DSC2). Characteristic phenotypes of ACM include ventricular arrhythmias, fibrofatty replacement of the myocardium, and desmosomal instability. While mechanistic linkages remain unknown, recent work has identified glucose synthase kinase (GSK3β) mislocalization as another common ACM phenotype....