Match!

Transcranial Impedance Changes during Sleep: A Rheoencephalography Study

Published on Jan 1, 2019in IEEE Journal of Translational Engineering in Health and Medicine
· DOI :10.1109/jtehm.2019.2898193
Amir H. Meghdadi8
Estimated H-index: 8
,
Djordje Popovic11
Estimated H-index: 11
+ 3 AuthorsAjay Verma9
Estimated H-index: 9
Cite
Abstract
Objective: To demonstrate the utility of rheoencephalography (REG) for measuring cerebral blood flow and fluid dynamics during different stages of sleep. Methods: Anteroposterior cranial electrical impedance was measured with concurrent polysomnography in a group of healthy subjects during sleep. Transcranial electrical impedance was characterized by measuring the peak-to-trough and envelope of the filtered pulsative REG signal as well as its frequency. The sensitivity of the REG amplitude to changes in cerebral blood flow (CBF) was confirmed by the analysis of the signal during breathing maneuvers with known effects on CBF. The mean amplitude and variability of the REG characteristic parameters were averaged across all participants and were compared between different stages of sleep. Results: Average transcranial impedance was significantly lower during non-REM stages N1 and N2, compared to other sleep stages, suggesting a decrease in CBF volume. Stage N3 showed the slowest frequency indicating a slow heart rate during this stage. N3 also had the lowest variability in frequency and peak-to-trough amplitude. Conclusion: Measurement of transcranial electrical conductivity may be a viable non-invasive method for monitoring any potential changes in intracranial fluid homeostasis. Clinical Impact: In the absence of other convenient non-invasive methods, using REG to track intracranial fluid dynamics during sleep can facilitate an improved understanding of pathogenesis in Alzheimer’s disease.
  • References (41)
  • Citations (0)
Cite
References41
Newest
#1Michael Bodo (Naval Medical Research Center)H-Index: 2
#1David Herzig (University of Bern)H-Index: 4
#2Prisca Eser (University of Bern)H-Index: 22
Last.Peter Achermann (UZH: University of Zurich)H-Index: 55
view all 6 authors...
#1Philippe Boudreau (McGill University)H-Index: 11
#2Wei-Hsien Yeh (McGill University)H-Index: 1
Last.Diane B. Boivin (McGill University)H-Index: 28
view all 4 authors...
#1Lulu Xie (URMC: University of Rochester Medical Center)H-Index: 4
#2Hongyi Kang (URMC: University of Rochester Medical Center)H-Index: 6
Last.Jeffrey J. Iliff (URMC: University of Rochester Medical Center)H-Index: 24
view all 10 authors...
#1Djordje PopovicH-Index: 1
#2Michael Bodo (WRAIR: Walter Reed Army Institute of Research)H-Index: 6
Last.Rocco A. Armonda (Walter Reed National Military Medical Center)H-Index: 7
view all 7 authors...
#1Jeffrey J. Iliff (UR: University of Rochester)H-Index: 24
#2Hedok Lee (SBU: Stony Brook University)H-Index: 14
Last.Helene Benveniste (SBU: Stony Brook University)H-Index: 37
view all 6 authors...
#1Jee Hoon Roh (WashU: Washington University in St. Louis)H-Index: 5
#2Yafei Huang (WashU: Washington University in St. Louis)H-Index: 5
Last.David M. HoltzmanH-Index: 42
view all 7 authors...
Cited By0
Newest
View next paperHeart period variability in sleep