Branding/Logomark minus Citation Combined Shape Icon/Bookmark-empty Icon/Copy Icon/Collection Icon/Close Copy 7 no author result Created with Sketch. Icon/Back Created with Sketch. Match!

Transcranial Impedance Changes during Sleep: A Rheoencephalography Study

Published on Jan 1, 2019in IEEE Journal of Translational Engineering in Health and Medicine
· DOI :10.1109/jtehm.2019.2898193
Amir H. Meghdadi8
Estimated H-index: 8
,
Djordje Popovic11
Estimated H-index: 11
+ 3 AuthorsAjay Verma9
Estimated H-index: 9
Abstract
Objective: To demonstrate the utility of rheoencephalography (REG) for measuring cerebral blood flow and fluid dynamics during different stages of sleep. Methods: Anteroposterior cranial electrical impedance was measured with concurrent polysomnography in a group of healthy subjects during sleep. Transcranial electrical impedance was characterized by measuring the peak-to-trough and envelope of the filtered pulsative REG signal as well as its frequency. The sensitivity of the REG amplitude to changes in cerebral blood flow (CBF) was confirmed by the analysis of the signal during breathing maneuvers with known effects on CBF. The mean amplitude and variability of the REG characteristic parameters were averaged across all participants and were compared between different stages of sleep. Results: Average transcranial impedance was significantly lower during non-REM stages N1 and N2, compared to other sleep stages, suggesting a decrease in CBF volume. Stage N3 showed the slowest frequency indicating a slow heart rate during this stage. N3 also had the lowest variability in frequency and peak-to-trough amplitude. Conclusion: Measurement of transcranial electrical conductivity may be a viable non-invasive method for monitoring any potential changes in intracranial fluid homeostasis. Clinical Impact: In the absence of other convenient non-invasive methods, using REG to track intracranial fluid dynamics during sleep can facilitate an improved understanding of pathogenesis in Alzheimer’s disease.
  • References (0)
  • Citations (0)
Cite
References0
Newest
Published on Jan 10, 2018in Frontiers in Physiology 3.39
David Herzig4
Estimated H-index: 4
(University of Bern),
Prisca Eser22
Estimated H-index: 22
(University of Bern)
+ 3 AuthorsPeter Achermann55
Estimated H-index: 55
(UZH: University of Zurich)
Objective: Measurements of heart rate variability (HRV) during sleep are becoming increasingly popular as sleep could provide an optimal state for HRV assessments. While sleep stages have been reported to affect HRV, the effect of sleep stages on the variance of HRV parameters were hardly investigated. We aimed to assess the variance of HRV parameters during the different sleep stages. Further, we tested the accuracy of an algorithm using HRV to identify a 5-min segment within an episode of slow...
4 Citations Source Cite
Published on Aug 1, 2015in Nature Reviews Neurology 19.82
Jenna M. Tarasoff-Conway2
Estimated H-index: 2
,
Roxana O. Carare20
Estimated H-index: 20
+ 13 AuthorsBerislav V. Zlokovic87
Estimated H-index: 87
The elimination of amyloid-β (Aβ) from the brain is already impaired at the prodromal stage of Alzheimer disease (AD), so restoration of the clearance systems of the brain might delay the onset of AD. This Review provides a comprehensive update on the brain's clearance systems, including the recent discoveries of the glymphatic system and meningeal lymphatic vessels—findings that have important implications for understanding the disrupted elimination of toxic proteins in AD.
314 Citations Source Cite
Published on Jan 1, 2015in Advances in Life Science and Technology
Yu.E. Moskalenko1
Estimated H-index: 1
,
Ju.V. Andreeva1
Estimated H-index: 1
The reoencephalographic method (REG) has been known for a number of decades. The history of this method includes loss of its popularity, years of oblivion and a second wave of recognition. Such a tumultuous history is common for methods based on physical principles, such as capacitance and resistance, when applied to physiology and medicine prior to serious preliminary investigations to establish indices for living tissues common to natural subjects. In this case because blood characterize by co...
4 Citations Source Cite
Published on Dec 1, 2013in Sleep 5.13
Philippe Boudreau11
Estimated H-index: 11
(McGill University),
Wei-Hsien Yeh1
Estimated H-index: 1
(McGill University)
+ 1 AuthorsDiane B. Boivin28
Estimated H-index: 28
(McGill University)
45 Citations Source Cite
Published on Oct 18, 2013in Science 41.06
Lulu Xie4
Estimated H-index: 4
(URMC: University of Rochester Medical Center),
Hongyi Kang6
Estimated H-index: 6
(URMC: University of Rochester Medical Center)
+ 9 AuthorsJeffrey J. Iliff24
Estimated H-index: 24
(URMC: University of Rochester Medical Center)
The conservation of sleep across all animal species suggests that sleep serves a vital function. We here report that sleep has a critical function in ensuring metabolic homeostasis. Using real-time assessments of tetramethylammonium diffusion and two-photon imaging in live mice, we show that natural sleep or anesthesia are associated with a 60% increase in the interstitial space, resulting in a striking increase in convective exchange of cerebrospinal fluid with interstitial fluid. In turn, conv...
1,238 Citations Source Cite
Published on Apr 18, 2013
Djordje Popovic1
Estimated H-index: 1
,
Michael Bodo6
Estimated H-index: 6
(WRAIR: Walter Reed Army Institute of Research)
+ 4 AuthorsRocco A. Armonda7
Estimated H-index: 7
(Walter Reed National Military Medical Center)
The ability of cerebral vasculature to regulate cerebral blood flow (CBF) in the face of changes in arterial blood pressure (SAP) or intracranial pressure (ICP) is an important guard against secondary ischemia in acute brain injuries, and official guidelines recommend that therapeutic decisions be guided by continuous monitoring of CBF autoregulation (AR). The common method for CBF AR monitoring, which rests on real-time derivation of the correlation coefficient (PRx) between slow oscillations i...
1 Citations Source Cite
Published on Mar 1, 2013in Journal of Clinical Investigation 13.25
Jeffrey J. Iliff24
Estimated H-index: 24
(UR: University of Rochester),
Hedok Lee14
Estimated H-index: 14
(SBU: Stony Brook University)
+ 3 AuthorsHelene Benveniste37
Estimated H-index: 37
(SBU: Stony Brook University)
The glymphatic system is a recently defined brain-wide paravascular pathway for cerebrospinal fluid (CSF) and interstitial fluid (ISF) exchange that facilitates efficient clearance of solutes and waste from the brain. CSF enters the brain along para-arterial channels to exchange with ISF, which is in turn cleared from the brain along para-venous pathways. Because soluble amyloid β clearance depends on glymphatic pathway function, we proposed that failure of this clearance system contributes to a...
282 Citations Source Cite
Published on Jan 1, 2013
Berislav V. Zlokovic87
Estimated H-index: 87
,
Blas Frangione94
Estimated H-index: 94
10 Citations
Published on Sep 5, 2012in Science Translational Medicine 16.71
Jee Hoon Roh5
Estimated H-index: 5
(WashU: Washington University in St. Louis),
Yafei Huang5
Estimated H-index: 5
(WashU: Washington University in St. Louis)
+ 4 AuthorsDavid M. Holtzman42
Estimated H-index: 42
Aggregation of β-amyloid (Aβ) in the brain begins to occur years before the clinical onset of Alzheimer’s disease (AD). Before Aβ aggregation, concentrations of extracellular soluble Aβ in the interstitial fluid (ISF) space of the brain, which are regulated by neuronal activity and the sleep-wake cycle, correlate with the amount of Aβ deposition in the brain seen later. The amount and quality of sleep decline with normal aging and to a greater extent in AD patients. How sleep quality as well as ...
191 Citations Source Cite
Published on Aug 15, 2012in Science Translational Medicine 16.71
Jeffrey J. Iliff24
Estimated H-index: 24
(URMC: University of Rochester Medical Center),
Minghuan Wang6
Estimated H-index: 6
(URMC: University of Rochester Medical Center)
+ 8 AuthorsSteven A. Goldman88
Estimated H-index: 88
(URMC: University of Rochester Medical Center)
Because it lacks a lymphatic circulation, the brain must clear extracellular proteins by an alternative mechanism. The cerebrospinal fluid (CSF) functions as a sink for brain extracellular solutes, but it is not clear how solutes from the brain interstitium move from the parenchyma to the CSF. We demonstrate that a substantial portion of subarachnoid CSF cycles through the brain interstitial space. On the basis of in vivo two-photon imaging of small fluorescent tracers, we showed that CSF enters...
1,126 Citations Source Cite
Cited By0
Newest