Mechanism of amyloid protein aggregation and the role of inhibitors
Abstract
Inhibition of amyloid β peptide (Aβ) aggregation is an important goal due to the connection of this process with Alzheimer’s disease. Traditionally, inhibitors were developed with an aim to retard the overall macroscopic aggregation. However, recent advances imply that approaches based on mechanistic insights may be more powerful. In such approaches, the microscopic steps underlying the aggregation process are identified, and it is established...
Paper Details
Title
Mechanism of amyloid protein aggregation and the role of inhibitors
Published Date
Feb 1, 2019
Journal
Volume
91
Issue
2
Pages
211 - 229
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