Anomalous Dense Liquid Condensates Host the Nucleation of Tumor Suppressor p53 Fibrils
Abstract
About half of human cancers are associated with mutations of the tumor suppressor p53. Gained oncogenic functions of the mutants have been related to aggregation behaviors of wild-type and mutant p53. The thermodynamic and kinetic mechanisms of p53 aggregation are poorly understood. Here we find that wild-type p53 forms an anomalous liquid phase. The liquid condensates exhibit several behaviors beyond the scope of classical phase transition...
Paper Details
Title
Anomalous Dense Liquid Condensates Host the Nucleation of Tumor Suppressor p53 Fibrils
Published Date
Feb 1, 2019
Journal
Volume
12
Pages
342 - 355
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