PIKfyve complex regulates early melanosome homeostasis required for physiological amyloid formation
Abstract
The metabolism of PI(3,5)P2 is regulated by the PIKfyve, VAC14 and FIG4 complex, whose mutations are associated with hypopigmentation in mice. These pigmentation defects indicate a key but yet unexplored physiological relevance of this complex in the biogenesis of melanosomes. Here we show that PIKfyve activity regulates formation of amyloid matrix composed of PMEL protein within early endosomes, called stage I melanosomes. PIKfyve activity...
Paper Details
Title
PIKfyve complex regulates early melanosome homeostasis required for physiological amyloid formation
Published Date
Jan 1, 2019
Journal
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