The binding interactions that maintain excitation–contraction coupling junctions in skeletal muscle
Abstract
Calcium for contraction of skeletal muscles is released via tetrameric ryanodine receptor (RYR1) channels of the sarcoplasmic reticulum (SR), which are assembled in ordered arrays called couplons at junctions where the SR abuts T tubules or plasmalemma. Voltage-gated Ca2+ (CaV1.1) channels, found in tubules or plasmalemma, form symmetric complexes called CaV tetrads that associate with and activate underlying RYR tetramers during membrane...
Paper Details
Title
The binding interactions that maintain excitation–contraction coupling junctions in skeletal muscle
Published Date
Feb 6, 2019
Volume
151
Issue
4
Pages
593 - 605
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