P489 Defective anti-microbial peptides expression in Crohn’s disease mucosa can be reversed by strengthening IL-22 signalling

The intestinal epithelium can be easily disrupted during gut inflammation as seen in inflammatory bowel diseases (IBD) such as ulcerative colitis (UC) or Crohn’s disease (CD). Aetiology of IBD is still not fully understood, but recent evidences suggest that the intestinal epithelium might play a major role in the development and perpetuation of IBD. In fact, disturbances in mechanisms that control the homeostasis, protection and repair of...