Original paper
Cellular Mechanisms of Etrolizumab Treatment in Inflammatory Bowel Disease
Abstract
Background: Anti-integrin therapy is a new frontline strategy in the treatment of inflammatory bowel diseases (IBD). The anti-β7 integrin antibody etrolizumab is currently being investigated for safety and efficacy in Crohn's disease (CD) and ulcerative colitis (UC) in several phase III trials. Mechanistically, etrolizumab is known to block β7 integrin ligand binding and reduces intestinal trafficking of β7-expressing cells. Etrolizumab blocks...
Paper Details
Title
Cellular Mechanisms of Etrolizumab Treatment in Inflammatory Bowel Disease
Published Date
Feb 1, 2019
Journal
Volume
10
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Notes
History