Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I
Abstract
Meiosis with a single round of DNA replication and two successive rounds of chromosome segregation requires specific cyclins associated with cyclin-dependent kinases (CDKs) to ensure its fidelity. But how cyclins control the distinctive meiosis is still largely unknown. In this study, we explored the role of cyclin B3 in female meiosis by generating Ccnb3 mutant mice via CRISPR/Cas9. Ccnb3 mutant oocytes characteristically arrested at metaphase...
Paper Details
Title
Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I
Published Date
Feb 15, 2019
Journal
Volume
218
Issue
5
Pages
1553 - 1563
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