Incidence of Anicteric Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome (VOD/SOS) and Efficacy of Defibrotide (DF) in Patients Post-HSCT in an Expanded-Access Program

IntroductionHepatic VOD/SOS is a progressive, potentially life-threatening complication of HSCT or nontransplant chemotherapy. VOD/SOS diagnosis by Baltimore criteria requires bilirubin >2 mg/dL; hyperbilirubinemia is not required by modified Seattle criteria, and may be a late finding in the progression of VOD/SOS. DF is approved to treat hepatic VOD/SOS with renal or pulmonary dysfunction post-HSCT in the US and Canada, and to treat severe...