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Vitamin A signaling and homeostasis in obesity, diabetes, and metabolic disorders

Published on May 1, 2019in Pharmacology & Therapeutics9.40
· DOI :10.1016/j.pharmthera.2019.01.006
William S. Blaner60
Estimated H-index: 60
(Columbia University)
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Abstract
Abstract Much evidence has accumulated in the literature over the last fifteen years that indicates vitamin A has a role in metabolic disease prevention and causation. This literature proposes that vitamin A can affect obesity development and the development of obesity-related diseases including insulin resistance, type 2 diabetes, hepatic steatosis and steatohepatitis, and cardiovascular disease. Retinoic acid, the transcriptionally active form of vitamin A, accounts for many of the reported associations. However, a number of proteins involved in vitamin A metabolism, including retinol-binding protein 4 (RBP4) and aldehyde dehydrogenase 1A1 (ALDH1A1, alternatively known as retinaldehyde dehydrogenase 1 or RALDH1), have also been identified as being associated with metabolic disease. Some of the reported effects of these vitamin A-related proteins are proposed to be independent of their roles in assuring normal retinoic acid homeostasis. This review will consider both human observational data as well as published data from molecular studies undertaken in rodent models and in cells in culture. The primary focus of the review will be on the effects that vitamin A per se and proteins involved in vitamin A metabolism have on adipocytes, adipose tissue biology, and adipose-related disease, as well as on early stage liver disease, including non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).
  • References (233)
  • Citations (3)
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References233
Newest
Published on Jan 1, 2019in Immunology4.15
Christopher G. Bazewicz1
Estimated H-index: 1
(PSU: Pennsylvania State University),
Saketh S. Dinavahi2
Estimated H-index: 2
(PSU: Pennsylvania State University)
+ 1 AuthorsGavin P. Robertson38
Estimated H-index: 38
Published on Aug 9, 2018in Mediators of Inflammation3.54
Luana de Mendonça Oliveira3
Estimated H-index: 3
(USP: University of São Paulo),
Franciane Mouradian Emidio Teixeira1
Estimated H-index: 1
(USP: University of São Paulo),
Maria Notomi Sato15
Estimated H-index: 15
(USP: University of São Paulo)
Vitamin A metabolite retinoic acid (RA) plays important roles in cell growth, differentiation, organogenesis, and reproduction and a key role in mucosal immune responses. RA promotes dendritic cells to express CD103 and to produce RA, enhances the differentiation of Foxp3
Published on Jun 1, 2018in Data in Brief
Massimiliano Perduca14
Estimated H-index: 14
(University of Verona),
Stefania Nicolis10
Estimated H-index: 10
(UNIPV: University of Pavia)
+ 2 AuthorsHugo L. Monaco21
Estimated H-index: 21
(University of Verona)
Abstract Retinol is transported in vertebrate plasma bound to a protein called retinol-binding protein (RBP4) so far believed to be specific for the vitamin. When the protein is saturated with retinol it binds tightly to another plasma protein, transthyretin while when not saturated with retinol it does not bind to TTR (Goodman, 1984). The X-ray structures of human RBP4, holo and devoid of retinol in its binding site are known to resolutions of 2.0 and 2.5 A (Cowan et al., 1990; Zanotti et al., ...
Published on Jun 1, 2018in Clinical Biochemistry2.43
Hong Cai1
Estimated H-index: 1
(Nanjing Medical University),
Sha Lu2
Estimated H-index: 2
(Nanjing Medical University)
+ 5 AuthorsZhifen Zhang2
Estimated H-index: 2
(Nanjing Medical University)
Abstract Objective To investigate the differential protein expression before and after menopause in women with nonalcoholic fatty liver disease (NAFLD) and to explore novel markers for menopausal NAFLD. Methods Eight serum samples collected from pre- or post-menopausal women with NAFLD were analysed by iTRAQ 2D-LC-MS/MS. Two protein candidates were selected and verified by enzyme-linked immunosorbent assay (ELISA) in serum samples collected from a one hundred and fifty-three female population su...
Published on Mar 7, 2018in Biochimica et Biophysica Acta3.79
Massimiliano Perduca14
Estimated H-index: 14
(University of Verona),
Stefania Nicolis10
Estimated H-index: 10
(UNIPV: University of Pavia)
+ 2 AuthorsHugo L. Monaco21
Estimated H-index: 21
(University of Verona)
Abstract RBP4 (plasma retinol-binding protein) is the 21 kDa transporter of all-trans retinol that circulates in plasma as a moderately tight 1:1 molar complex of the vitamin with the protein. RBP4 is primarily synthesized in the liver but is also produced by adipose tissue and circulates bound to a larger protein, transthyretin, TTR, that serves to increase its molecular mass and thus avoid its elimination by glomerular filtration. This paper reports the high resolution three-dimensional struct...
Published on Mar 20, 2018in International Journal of Molecular Sciences4.18
Xavier Palomer26
Estimated H-index: 26
,
Emma Barroso19
Estimated H-index: 19
+ 6 AuthorsManuel Vázquez-Carrera36
Estimated H-index: 36
Research in recent years on peroxisome proliferator-activated receptor (PPAR)β/δ indicates that it plays a key role in the maintenance of energy homeostasis, both at the cellular level and within the organism as a whole. PPARβ/δ activation might help prevent the development of metabolic disorders, including obesity, dyslipidaemia, type 2 diabetes mellitus and non-alcoholic fatty liver disease. This review highlights research findings on the PPARβ/δ regulation of energy metabolism and the develop...
Published on Mar 1, 2018in Journal of Endocrinology4.38
Sung Wook Park15
Estimated H-index: 15
,
Shawna D. Persaud7
Estimated H-index: 7
(UMN: University of Minnesota)
+ 3 AuthorsLi-Na Wei28
Estimated H-index: 28
Published on Jan 10, 2018in Diabetes7.20
Di Yang2
Estimated H-index: 2
(University of California, Berkeley),
Marta G. Vuckovic1
Estimated H-index: 1
(University of California, Berkeley)
+ 7 AuthorsJoseph L. Napoli33
Estimated H-index: 33
(University of California, Berkeley)
Pharmacological dosing of all- trans -retinoic acid (atRA) controls adiposity in rodents by inhibiting adipogenesis and inducing fatty acid oxidation. Retinol dehydrogenases (Rdh) catalyze the first reaction that activate retinol into atRA. This study examined post-natal contributions of Rdh10 to atRA biosynthesis and physiological functions of endogenous atRA. Embryonic fibroblasts from Rdh10 heterozygote hypomorphs or with a total Rdh10 knockout exhibit decreased atRA biosynthesis and escalate...
Published on Dec 1, 2017in Trends in Endocrinology and Metabolism9.78
Francesc Villarroya48
Estimated H-index: 48
(University of Barcelona),
Aleix Gavaldà-Navarro7
Estimated H-index: 7
(University of Barcelona)
+ 2 AuthorsMarta Giralt40
Estimated H-index: 40
(University of Barcelona)
Brown adipose tissue (BAT) is responsible for adaptive non-shivering thermogenesis. Moreover, brown fat secretes regulatory factors, so-called brown adipokines, that have autocrine, paracrine, and endocrine actions. Brown adipokines are either polypeptides or nonpeptidic molecules including lipid molecules and microRNAs. The secretory properties of brown fat are essential for tissue remodeling adaptations to thermogenic necessities. The endocrine properties of brown adipokines are thought to con...
Cited By3
Newest
Rubella is a systemic virus infection that is usually mild. It can, however, cause severe birth defects known as the congenital rubella syndrome (CRS) when infection occurs early in pregnancy. As many as 8%–13% of children with CRS developed autism during the rubella epidemic of the 1960s compared to the background rate of about 1 new case per 5000 children. Rubella infection and CRS are now rare in the U.S. and in Europe due to widespread vaccination. However, autism rates have risen dramatical...
Published on Jun 11, 2019in Diabetes Care15.27
Jiahua Fan (SYSU: Sun Yat-sen University), Songping Yin (SYSU: Sun Yat-sen University)+ 12 AuthorsXiu-hong Lin1
Estimated H-index: 1
(SYSU: Sun Yat-sen University)
OBJECTIVE To explore the association of serum retinol-binding protein 4 (RBP4) levels and risk for the development of type 2 diabetes in individuals with prediabetes. RESEARCH DESIGN AND METHODS A population-based prospective study was conducted among 1,011 Chinese participants with prediabetes (average age 55.6 ± 7.2 years). Incident type 2 diabetes was diagnosed according to the American Diabetes Association 2010 criteria. Serum RBP4 levels were measured using a commercially available ELISA. W...
All-trans retinoic acid (AtRA), an active metabolite of vitamin A, is recognized for its classical action as an endocrine hormone that triggers genomic effects mediated through nuclear receptors RA receptors (RARs). New evidence shows that atRA-mediated cellular responses are biphasic with rapid and delayed responses. Most of these rapid atRA responses are the outcome of its binding to cellular retinoic acid binding protein 1 (CRABP1) that is predominantly localized in cytoplasm and binds to atR...
Published on Jul 11, 2019in Nutrients4.17
Lourdes Mounien12
Estimated H-index: 12
,
Franck Tourniaire16
Estimated H-index: 16
,
Jean-François Landrier24
Estimated H-index: 24
This review summarizes current knowledge on the biological relevance of carotenoids and some of their metabolites in obesity management. The relationship between carotenoids and obesity is considered in clinical studies and in preclinical studies. Adipose tissue is a key organ in obesity etiology and the main storage site for carotenoids. We thus first describe carotenoid metabolism in adipocyte and adipose tissue and the effects of carotenoids on biological processes in adipose tissue that may ...
Published on Jun 14, 2019in Journal of Cell Biology8.89
Ryan J. Schulze13
Estimated H-index: 13
(Mayo Clinic),
Micah B. Schott4
Estimated H-index: 4
(Mayo Clinic)
+ 2 AuthorsMark A. McNiven54
Estimated H-index: 54
(Mayo Clinic)
The liver performs numerous vital functions, including the detoxification of blood before access to the brain while simultaneously secreting and internalizing scores of proteins and lipids to maintain appropriate blood chemistry. Furthermore, the liver also synthesizes and secretes bile to enable the digestion of food. These diverse attributes are all performed by hepatocytes, the parenchymal cells of the liver. As predicted, these cells possess a remarkably well-developed and complex membrane t...
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