P089 Extensive characterisation of cellular sources of IL-22BP in inflammatory bowel diseases indicates that T cells do not express IL-22BP

IL-22 is an epithelium-targeting cytokine of major importance in the gut. Its secretion is dramatically increased during inflammatory bowel diseases (IBD) flares. Actions of IL-22 during gut inflammation have been largely addressed, placing IL-22 as a chief cytokine to orchestrate intestinal epithelial cell (IEC) barrier functions (AMPs and mucus expression induction) and regeneration and therefore to promote mucosal healing. However, excessive...