Detection of Base Analogs Incorporated During DNA Replication by Nanopore Sequencing

Abstract
DNA synthesis is a fundamental requirement for cell proliferation and DNA repair, but no tools exist to identify the location, direction and speed of replication forks with base pair resolution. Mammalian cells have the ability to incorporate thymidine analogs along with the natural A, T, G and C bases during DNA synthesis, which allows for labelling of replicating or repaired DNA. Most sequencing platforms rely on base-pairing to identify the...
Paper Details
Title
Detection of Base Analogs Incorporated During DNA Replication by Nanopore Sequencing
Published Date
Feb 14, 2019
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