RNAs in the spliceosome: Insight from cryoEM structures

Volume: 10, Issue: 3
Published: Feb 6, 2019
Abstract
Pre‐mRNA splicing is catalyzed by the spliceosome, a multimegadalton RNA–protein complex. The spliceosome undergoes dramatic compositional and conformational changes through the splicing cycle, forming at least 10 distinct complexes. Recent high‐resolution cryoEM structures of various spliceosomal complexes revealed unprecedented details of this large molecular machine. This review highlights insight into the structure and function of the...
Paper Details
Title
RNAs in the spliceosome: Insight from cryoEM structures
Published Date
Feb 6, 2019
Volume
10
Issue
3
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