Osh Proteins Control Nanoscale Lipid Organization Necessary for PI(4,5)P2 Synthesis
Abstract
The plasma membrane (PM) is composed of a complex lipid mixture that forms heterogeneous membrane environments. Yet, how small-scale lipid organization controls physiological events at the PM remains largely unknown. Here, we show that ORP-related Osh lipid exchange proteins are critical for the synthesis of phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P2], a key regulator of dynamic events at the PM. In real-time assays, we find that...
Paper Details
Title
Osh Proteins Control Nanoscale Lipid Organization Necessary for PI(4,5)P2 Synthesis
Published Date
Sep 1, 2019
Journal
Volume
75
Issue
5
Pages
1043 - 1057.e8
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