Trazodone use and risk of dementia: A population-based cohort study

Background In vitro and animal studies have suggested that trazodone, a licensed antidepressant, may protect against dementia. However, no studies have been conducted to assess the effect of trazodone on dementia in humans. This electronic health records study assessed the association between trazodone use and the risk of developing dementia in clinical practice. Methods and findings The Health Improvement Network (THIN), an archive of...