Brain region-specific alterations of RNA editing in PDE8A mRNA in suicide decedents

Volume: 9, Issue: 1
Published: Feb 15, 2019
Abstract
Phosphodiesterases (PDE) are key modulators of signal transduction and are involved in inflammatory cell activation, memory and cognition. There is a two-fold decrease in the expression of phosphodiesterase 8A (PDE8A) in the temporal cortex of major depressive disorder (MDD) patients. Here, we studied PDE8A mRNA-editing profile in two architectonically distinct neocortical regions in a clinically well-characterized cohort of age- and sex-matched...
Paper Details
Title
Brain region-specific alterations of RNA editing in PDE8A mRNA in suicide decedents
Published Date
Feb 15, 2019
Volume
9
Issue
1
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