Brain region-specific alterations of RNA editing in PDE8A mRNA in suicide decedents
Abstract
Phosphodiesterases (PDE) are key modulators of signal transduction and are involved in inflammatory cell activation, memory and cognition. There is a two-fold decrease in the expression of phosphodiesterase 8A (PDE8A) in the temporal cortex of major depressive disorder (MDD) patients. Here, we studied PDE8A mRNA-editing profile in two architectonically distinct neocortical regions in a clinically well-characterized cohort of age- and sex-matched...
Paper Details
Title
Brain region-specific alterations of RNA editing in PDE8A mRNA in suicide decedents
Published Date
Feb 15, 2019
Journal
Volume
9
Issue
1
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