IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling
Abstract
Activation of endoplasmic reticulum (ER) stress/the unfolded protein response (UPR) has been linked to cancer, but the molecular mechanisms are poorly understood and there is a paucity of reagents to translate this for cancer therapy. Here, we report that an IRE1α RNase-specific inhibitor, MKC8866, strongly inhibits prostate cancer (PCa) tumor growth as monotherapy in multiple preclinical models in mice and shows synergistic antitumor effects...
Paper Details
Title
IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling
Published Date
Jan 24, 2019
Journal
Volume
10
Issue
1
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