Cysteinyl Leukotriene Receptor 2 Drives IL-33-Mediated Aspirin Sensitivity Through A Platelet Dependent Mechanism

Cysteinyl leukotrienes (cysLTs) facilitate mucosal type 2 (eosinophilic) immunopathology, especially in aspirin-exacerbated respiratory disease (AERD), by incompletely understood mechanisms. Leukotriene C4 (LTC4) acts at platelet- and epithelial-associated type 2 cysLT receptors (CysLT2R) to modulate eosinophilic airway inflammation. Because platelets constitutively express IL-33 protein, which is essential to the induction of type 2...