Mitochondria-centric bioenergetic characteristics in cancer stem-like cells
Abstract
Metabolic and genotoxic stresses that arise during tumor progression and anti-cancer treatment, respectively, can impose a selective pressure to promote cancer evolution in the tumor microenvironment. This process ultimately selects for the most “fit” clones, which generally have a cancer stem cell like phenotype with features of drug resistance, epithelial-mesenchymal transition, invasiveness, and high metastatic potential. From a bioenergetics...
Paper Details
Title
Mitochondria-centric bioenergetic characteristics in cancer stem-like cells
Published Date
Feb 1, 2019
Volume
42
Issue
2
Pages
113 - 127
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