Structural rearrangements generate cell-specific, gene-independent CRISPR-Cas9 loss of fitness effects
Abstract
CRISPR-Cas9 genome editing is widely used to study gene function, from basic biology to biomedical research. Structural rearrangements are a ubiquitous feature of cancer cells and their impact on the functional consequences of CRISPR-Cas9 gene-editing has not yet been assessed. Utilizing CRISPR-Cas9 knockout screens for 250 cancer cell lines, we demonstrate that targeting structurally rearranged regions, in particular tandem or interspersed...
Paper Details
Title
Structural rearrangements generate cell-specific, gene-independent CRISPR-Cas9 loss of fitness effects
Published Date
Feb 5, 2019
Journal
Volume
20
Issue
1
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