Cyclin B3 promotes anaphase I onset in oocyte meiosis
Abstract
Meiosis poses unique challenges because two rounds of chromosome segregation must be executed without intervening DNA replication. Mammalian cells express numerous temporally regulated cyclins, but how these proteins collaborate to control meiosis remains poorly understood. Here, we show that female mice genetically ablated for cyclin B3 are viable—indicating that the protein is dispensable for mitotic divisions—but are sterile. Mutant oocytes...
Paper Details
Title
Cyclin B3 promotes anaphase I onset in oocyte meiosis
Published Date
Feb 5, 2019
Journal
Volume
218
Issue
4
Pages
1265 - 1281
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