Cannabinoid CB₁ and CB₂ receptor mechanisms underlie cannabis reward and aversion in rats

Background and Purpose Endocannabinoids are critically involved in brain reward functions, mediated by activation of CB 1 receptors, reflecting their high density in the brain. However, the recent discovery of CB 2 receptors in the brain, particularly in the midbrain dopamine neurons, has challenged this view and inspired us to re‐examine the roles of both CB 1 and CB 2 receptors in the effects of cannabis. Experimental Approach In the present...