Structural basis for the bypass of the major oxaliplatin–DNA adducts by human DNA polymerase η
Abstract
Oxaliplatin, together with cisplatin, is among the most important drugs used in cancer chemotherapy. Oxaliplatin, which contains a bulky diaminocyclohexane (DACH) moiety, kills cancer cells mainly by producing (DACH)Pt-GpG intrastrand cross-links that impede transcription. The Pt-GpG tolerance by translesion DNA synthesis (TLS) polymerases contributes to the resistance of tumors to platinum-based chemotherapy. In particular, human DNA polymerase...
Paper Details
Title
Structural basis for the bypass of the major oxaliplatin–DNA adducts by human DNA polymerase η
Published Date
Feb 28, 2019
Journal
Volume
476
Issue
4
Pages
747 - 758
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