Do soft anions promote protein denaturation through binding interactions? A case study using ribonuclease A
Abstract
It has long been known that large soft anions like bromide, iodide and thiocyanate are protein denaturing agents, but their mechanism of action is still unclear. In this work we have investigated the protein denaturing properties of these anions using Ribonuclease A (RNase A) as a model protein system. Salt-induced perturbations to the protein folding free energy were determined using differential scanning calorimetry and the results demonstrate...
Paper Details
Title
Do soft anions promote protein denaturation through binding interactions? A case study using ribonuclease A
Published Date
Jan 1, 2019
Journal
Volume
9
Issue
6
Pages
3416 - 3428
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