Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence

Volume: 38, Issue: 5, Pages: 1
Published: Mar 1, 2019
Abstract
Ageing is the biggest risk factor for cardiovascular disease. Cellular senescence, a process driven in part by telomere shortening, has been implicated in age‐related tissue dysfunction. Here, we address the question of how senescence is induced in rarely dividing/post‐mitotic cardiomyocytes and investigate whether clearance of senescent cells attenuates age‐related cardiac dysfunction. During ageing, human and murine cardiomyocytes acquire a...
Paper Details
Title
Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence
Published Date
Mar 1, 2019
Volume
38
Issue
5
Pages
1
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