Rho-inhibition and neuroprotective effect on rotenone-treated dopaminergic neurons in vitro
Abstract
Mesencephalic cell cultures are a good model to study the vulnerability of dopaminergic neurons and reproduce, in vitro, experimental models of Parkinson's disease. Rotenone associated as an environmental neurotoxin related to PD, is able to provoke dopaminergic neuron degeneration by inhibiting complex I of the mitochondrial respiratory chain and by inducing accumulation of α-synuclein. Recently, rotenone has been described to activate RhoA, a...
Paper Details
Title
Rho-inhibition and neuroprotective effect on rotenone-treated dopaminergic neurons in vitro
Published Date
May 1, 2019
Journal
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