Hydrogen sulfide regulates muscle RING finger‐1 protein S‐sulfhydration at Cys⁴⁴ to prevent cardiac structural damage in diabetic cardiomyopathy

Background and Purpose Hydrogen sulfide (H 2 S) plays important roles as a gasotransmitter in pathologies. Increased expression of the E3 ubiquitin ligase, muscle RING finger‐1 (MuRF1), may be involved in diabetic cardiomyopathy. Here we have investigated whether and how exogenous H 2 S alleviates cardiac muscle degradation through modifications of MuRF1 S‐sulfhydration in db/db mice. Experimental Approach Neonatal rat cardiomyocytes were...