Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis

Volume: 10, Issue: 1
Published: Apr 12, 2019
Abstract
Hypothalamic neurons expressing the anorectic peptide Pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here, we show that Steroid Receptor Coactivator-1 (SRC-1) interacts with a target of leptin receptor activation, phosphorylated STAT3, to potentiate Pomc transcription. Deletion of SRC-1 in Pomc neurons in mice attenuates their depolarization by leptin, decreases Pomc expression and increases food intake leading to high-fat...
Paper Details
Title
Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis
Published Date
Apr 12, 2019
Volume
10
Issue
1
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