Excess growth hormone suppresses DNA damage repair in epithelial cells
Abstract
Growth hormone (GH) decreases with age, and GH therapy has been advocated by some to sustain lean muscle mass and vigor in aging patients and advocated by athletes to enhance performance. Environmental insults and aging lead to DNA damage, which - if unrepaired - results in chromosomal instability and tumorigenesis. We show that GH suppresses epithelial DNA damage repair and blocks ataxia telangiectasia mutated (ATM) kinase autophosphorylation...
Paper Details
Title
Excess growth hormone suppresses DNA damage repair in epithelial cells
Published Date
Feb 7, 2019
Journal
Volume
4
Issue
3
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