A single point mutation in the TRPC3 lipid-recognition window generates supersensitivity to benzimidazole channel activators
Abstract
Mutation of a single residue within the recently identified lipid (diacylglycerol) recognition window of TRPC3 (G652A) was found to abolish channel activation via endogenous lipid mediators while retaining sensitivity to the non-lipid activator GSK1702934A (abb. GSK). The mechanism of this change in chemical sensing by TRPC3 was analysed by whole-cell and single channel electrophysiology as well as Ca2+ imaging. Currents initiated by GSK or the...
Paper Details
Title
A single point mutation in the TRPC3 lipid-recognition window generates supersensitivity to benzimidazole channel activators
Published Date
May 1, 2019
Journal
Volume
79
Pages
27 - 34
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