High α-galactosidase A over expression and/or mitochondrial dysfunction may inhibit efficacy of gene therapy for Fabry disease

Given conflicting findings of previous studies, much remains to be understood regarding a volume-outcomes relationship (VOR) in transcatheter aortic valve replacement (TAVR).The purpose of this study was: 1) to determine if, after the initial learning curve (LC), a VOR for balloon-expandable (BE) TAVR persisted; and 2) to determine if LCs and VORs differed across different device generations.Data collected by the TVT registry for BE valve...