It takes a village: channeling fatty acid metabolism and triacylglycerol formation via protein interactomes

The storage and degradation of long-chain FA underpin eukaryotic energy metabolism. The two extremes of dysregulated energy metabolism, obesity and cachexia, are linked to major noninfectious chronic disorders, including diabetes, cardiovascular disease, and cancer. Thus, for the past 60 years, scientists and clinicians have worked to understand FAs and triacylglycerol (TAG) in terms of their pathways of synthesis, regulation, and physiological...