FLT3-ITD impedes retinoic acid, but not arsenic, responses in murine acute promyelocytic leukemias
Abstract
Acute promyelocytic leukemia (APL) is often associated with activating FLT3 signaling mutations. These are highly related to hyperleukocytosis, a major adverse risk factor with chemotherapy-based regimens. APL is a model for oncogene-targeted therapies: all-trans retinoic acid (ATRA) and arsenic both target and degrade its ProMyelocytic Leukemia/Retinoic Acid Receptor α (PML/RARA) driver. The combined ATRA/arsenic regimen now cures virtually all...
Paper Details
Title
FLT3-ITD impedes retinoic acid, but not arsenic, responses in murine acute promyelocytic leukemias
Published Date
Mar 28, 2019
Journal
Volume
133
Issue
13
Pages
1495 - 1506
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Notes
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