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Heat stress reduces Eimeria spp. infection and interferes with C. perfringens infection via activation of the hypothalamic-pituitary-adrenal axis

Published on Apr 1, 2019in Research in Veterinary Science 1.75
· DOI :10.1016/j.rvsc.2019.01.026
Atilio Sersun Calefi7
Estimated H-index: 7
(USP: University of São Paulo),
Catarina Augusta de Queiroz Nunes (USP: University of São Paulo)+ 3 AuthorsJoão Palermo-Neto29
Estimated H-index: 29
(USP: University of São Paulo)
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Abstract
Abstract Heat stress has a relevant effect on animal health and productivity. Stress and environmental changes can contribute to disease development, such as avian necrotic enteritis (NE). The goal of this study was to analyze the effects of heat stress applied to broiler chickens in an experimental model of co-infection with Clostridium perfringens and Eimeria spp. Therefore, the current study was designed to analyze the effect of heat stress to broiler chickens in an experimental model of infection or co-infection with Clostridium perfringens and Eimeria spp. C. perfringens was given in the poultry feed and the Eimeria infection was induced by gavage with a live oocysts vaccine dose 30 times higher than the manufacturer recommendation. We observed a reduction in the secretory IgA concentration in the jejunum and ileum in heat-stressed chickens compared to non-stressed chickens. Decreased maximum scores of intestinal necrosis, crypt abscesses and transmural lesions were observed in the heat-stressed chickens co-infected and infected with Eimeria compared to the respective unstressed groups. Heat stress caused an increase the intestinal lesion scores in chickens infected with C. perfringens only. The crypt depth was greater in chickens from the heat-stressed groups compared to the non-stressed groups. We also demonstrated that HS decreased infection and/or Eimeria development in the intestinal epithelium, reducing the harmful potential of C. perfringens .
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References31
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Published on Apr 1, 2017in Veterinary Immunology and Immunopathology 1.85
W.M. Quinteiro-Filho11
Estimated H-index: 11
(USP: University of São Paulo),
Atilio Sersun Calefi7
Estimated H-index: 7
(USP: University of São Paulo)
+ 6 AuthorsJoão Palermo-Neto29
Estimated H-index: 29
(USP: University of São Paulo)
Abstract A high ambient temperature is a highly relevant stressor in poultry production. Heat stress (HS) has been reported to reduce animal welfare, performance indices and increase Salmonella susceptibility. Salmonella spp. are major zoonotic pathogen that cause over 1 billion of human infections worldwide annually. Therefore, the current study was designed to analyze the effect of heat stress on Salmonella infection in chickens through modulation of the immune responses. Salmonella Enteritidi...
11 Citations Source Cite
Published on May 1, 2016in Poultry Science 2.03
Atilio Sersun Calefi7
Estimated H-index: 7
,
Juliana Garcia da Silva Fonseca4
Estimated H-index: 4
+ 6 AuthorsJoão Palermo-Neto29
Estimated H-index: 29
The gut-brain axis is known to modulate behavioral and immune responses in animals; evidence supporting this modulation in chickens, however, is elusive. Here, we analyzed the effects of heat stress and/orClostridium perfringens (CP) infection on behavior, intestinal morphology, brain activity, and corticosterone serum levels in chickens. Broilers were randomly divided into 5 equal groups: a naive group (N), a thioglycolate group (T), a thioglycolate heat-stressed group (T/HS35), an infected gro...
8 Citations Source Cite
Published on Mar 1, 2016in Brazilian Journal of Poultry Science 0.61
Atilio Sersun Calefi7
Estimated H-index: 7
(USP: University of São Paulo),
W.M. Quinteiro-Filho11
Estimated H-index: 11
(USP: University of São Paulo)
+ 7 AuthorsJoão Palermo-Neto29
Estimated H-index: 29
(USP: University of São Paulo)
Dexamethasone (DEX) is a corticoid hormone that is experimentally used to mimic the effects of increased levels of endogenous corticosterone observed during the stress response. Currently, stress is considered one of the major predisposing factors for diseases in the poultry industry. The aim of this study was to analyze the effects of DEX and/or of a 20-fold coccidial vaccine dose on leukocyte phenotypes in the spleen and cecal tonsils of chickens. Twenty specific-pathogen-free (SPF) Leghorn ch...
4 Citations Source Cite
Published on Mar 1, 2016in Veterinary Immunology and Immunopathology 1.85
Atilio Sersun Calefi7
Estimated H-index: 7
(USP: University of São Paulo),
Adriana de Siqueira6
Estimated H-index: 6
(USP: University of São Paulo)
+ 6 AuthorsJoão Palermo-Neto29
Estimated H-index: 29
(USP: University of São Paulo)
Abstract Avian necrotic enteritis (NE) induced by Clostridium perfringens is a disease that affects mainly the first weeks of poultry’s life. The pathogenesis of NE is complex and involves the combination of several factors, such as co-infection with different species of coccidia, immunosuppression and stress. Stress is one of the main limiting factors in poultry production. Although several studies emphasized the effects of stress on immunity, few works analyzed these effects on immunoglobulins...
8 Citations Source Cite
Published on Nov 2, 2015in Avian Pathology 1.96
V. Tsiouris2
Estimated H-index: 2
,
I. Georgopoulou7
Estimated H-index: 7
+ 3 AuthorsP. Fortomaris5
Estimated H-index: 5
(A.U.Th.: Aristotle University of Thessaloniki)
Cold stress is a physical environmental stressor with significant effect on the poultry industry. The aim of the present study was to investigate the effect of cold stress as a predisposing factor for necrotic enteritis in broiler chicks. The experimental challenge model included an oral inoculation with 10-fold dose of attenuated anticoccidial vaccine and multiple oral inoculations with a specific strain of Clostridium perfringens. Birds were either challenged or not as described above, and eit...
9 Citations Source Cite
Published on Mar 4, 2015in Avian Pathology 1.96
Tsiouris2
Estimated H-index: 2
(A.U.Th.: Aristotle University of Thessaloniki),
I. Georgopoulou7
Estimated H-index: 7
(A.U.Th.: Aristotle University of Thessaloniki)
+ 3 AuthorsP. Fortomaris5
Estimated H-index: 5
(A.U.Th.: Aristotle University of Thessaloniki)
Stocking density is a management factor which has critical implications for the poultry industry. The aim of the present study was to investigate the effect of high stocking density as a predisposing factor in an experimental model of necrotic enteritis in broiler chicks. The experimental challenge model included an oral inoculation with 10-fold dose of attenuated anticoccidial vaccine and multiple oral inoculations with a specific strain of Clostridium perfringens. Two hundred and forty as hatc...
16 Citations Source Cite
Published on Jun 1, 2014in Poultry Science 2.03
Atilio Sersun Calefi7
Estimated H-index: 7
(USP: University of São Paulo),
Bruno Takashi Bueno Honda3
Estimated H-index: 3
(USP: University of São Paulo)
+ 7 AuthorsJoão Palermo-Neto29
Estimated H-index: 29
(USP: University of São Paulo)
14 Citations Source Cite
Published on Apr 24, 2013in Open Access Journal
Lucas J. Lara1
Estimated H-index: 1
,
Marcos H. Rostagno13
Estimated H-index: 13
(USDA: United States Department of Agriculture)
Understanding and controlling environmental conditions is crucial to successful poultry production and welfare. Heat stress is one of the most important environmental stressors challenging poultry production worldwide. The detrimental effects of heat stress on broilers and laying hens range from reduced growth and egg production to decreased poultry and egg quality and safety. Moreover, the negative impact of heat stress on poultry welfare has recently attracted increasing public awareness and c...
190 Citations Source Cite
Published on Oct 1, 2012in Avian Pathology 1.96
W.M. Quinteiro-Filho11
Estimated H-index: 11
(USP: University of São Paulo),
A.V. Gomes3
Estimated H-index: 3
(USP: University of São Paulo)
+ 5 AuthorsJoão Palermo-Neto29
Estimated H-index: 29
(USP: University of São Paulo)
Stressful situations reduce the welfare, production indices and immune status of chickens. Salmonella spp. are a major zoonotic pathogens that annually cause over 1 billion infections worldwide. We therefore designed the current experiment to analyse the effects of 31±1°C heat stress (HS) (from 35 to 41 days) on performance parameters, Salmonella invasion and small intestine integrity in broiler chickens infected with Salmonella Enteritidis. We observed that HS decreased body weight gain and fee...
63 Citations Source Cite
Published on Jun 1, 2012in Journal of Animal Science 1.70
W.M. Quinteiro-Filho11
Estimated H-index: 11
(USP: University of São Paulo),
M. V. Rodrigues1
Estimated H-index: 1
(USP: University of São Paulo)
+ 5 AuthorsJoão Palermo-Neto29
Estimated H-index: 29
(USP: University of São Paulo)
Studies on the environmental conse- quences of stress are relevant for economic and animal welfare reasons. We recently reported that long-term heat stressors (31 ± 1oC and 36 ± 1oC for 10 h/d) applied to broiler chickens (Gallus gallus domesticus) from d 35 to 42 of life increased serum corticosterone con- centrations, decreased performance variables and the macrophage oxidative burst, and produced mild, mul- tifocal acute enteritis. Being cognizant of the relevance of acute heat stress on trop...
65 Citations Source Cite
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