Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues
Abstract
African swine fever virus (ASFV) is contagious and can cause highly lethal disease in pigs. ASFV DNA ligase (AsfvLIG) is one of the most error-prone ligases identified to date; it catalyzes DNA joining reaction during DNA repair process of ASFV and plays important roles in mutagenesis of the viral genome. Here, we report four AsfvLIG:DNA complex structures and demonstrate that AsfvLIG has a unique N-terminal domain (NTD) that plays critical...
Paper Details
Title
Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues
Published Date
Jan 23, 2019
Journal
Volume
10
Issue
1
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