Amelioration of Early Markers of Diabetic Nephropathy by Linagliptin in Fructose-Streptozotocin-Induced Type 2 Diabetic Rats

Early prediction and clinical intervention are extremely important in order to delay or hinder diabetic nephropathy (DN) progression.This study aimed to detect early signs of DN and study the potential ameliorating effect of the dipeptidyl peptidase-4 inhibitor, linagliptin, on some early markers for DN in fructose-streptozotocin (Fr-STZ)-induced diabetic rats.Fr-STZ rats were treated with either linagliptin (3 mg/kg p.o. daily), metformin (350...