Engineering of high-precision base editors for site-specific single nucleotide replacement
Abstract
RNA-guided nucleases of the CRISPR/Cas type can be repurposed as programmable nucleotide deaminases to mediate targeted nucleotide substitutions. Such base editors have enormous potential in genome editing, gene therapy and precision breeding. However, current editors suffer from limited specificity in that they edit different and/or multiple bases within a larger sequence window. Using cytidine deaminase base editors that elicit C-to-T...
Paper Details
Title
Engineering of high-precision base editors for site-specific single nucleotide replacement
Published Date
Jan 25, 2019
Journal
Volume
10
Issue
1
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