Durable anticancer immunity from intratumoral administration of IL-23, IL-36γ, and OX40L mRNAs
Abstract
Many solid cancers contain dysfunctional immune microenvironments. Immune system modulators that initiate responses to foreign pathogens could be promising candidates for reigniting productive responses toward tumors. Interleukin-1 (IL-1) and IL-12 cytokine family members cooperate at barrier tissues after microbial invasion, in human inflammatory diseases, and in antitumoral immunity. IL-36γ, in classic alarmin fashion, acts in damaged tissues,...
Paper Details
Title
Durable anticancer immunity from intratumoral administration of IL-23, IL-36γ, and OX40L mRNAs
Published Date
Jan 30, 2019
Volume
11
Issue
477
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