Archival ReportThe Relationship Between Toxoplasma Gondii Infection and Mood Disorders in the Third National Health and Nutrition Survey

Published on Aug 15, 2012in Biological Psychiatry11.501
路 DOI :10.1016/j.biopsych.2012.01.003
Brad D. Pearce20
Estimated H-index: 20
Deanna Kruszon-Moran25
Estimated H-index: 25
Jeffrey L. Jones49
Estimated H-index: 49
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  • Citations (83)
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#1Ibrahim F. RehanH-Index: 1
#2Motamed Elsayed Mahmoud (Sohag University)H-Index: 4
Last. Abd El-Latif Hesham (Beni-Suef University)H-Index: 1
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Toxoplasma gondii is associated with physiological and psychiatric perturbations. The immune response is interrelated to the progress of anhedonia and despair symptoms of T. gondii-infected subjects. We recently reported that serum N-glycans were altered in mice displayed depressive-like behaviors. However, a novel biomarker that correlated to T. gondii infection and associated behaviors is demanded. Glycomics has been used to find affected glycoproteins during depression. The objective of this ...
#1Kano S-I. (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 1
#2Colin A. Hodgkinson (NIH: National Institutes of Health)H-Index: 43
Last. Akira Sawa (Johns Hopkins University)H-Index: 66
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Clinical studies frequently report that patients with major mental illness such as schizophrenia and bipolar disorder have co-morbid physical conditions, suggesting that systemic alterations affecting both brain and peripheral tissues might underlie the disorders. Numerous studies have reported elevated levels of anti-Toxoplasma gondii (T. gondii) antibodies in patients with major mental illnesses, but the underlying mechanism was unclear. Using multidisciplinary epidemiological, cell biological...
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Background and Aims: Infection with the parasite Toxoplasma gondii has been associated with bipolar disorder in several countries other than Mexico. Therefore, we sought to determine the association between seropositivity to T. gondii and bipolar disorder in a Mexican population. Methods: We performed an age- and gender-matched case鈥揷ontrol study of 66 patients with bipolar disorder (WHO International Classification of Diseases, 10th Revision code: F31) and 396 subjects without this disorder fro...
Toxoplasma gondii (T. gondii) is an intracellular parasite infecting one third of the world鈥檚 population. Latent T. gondii infection has been associated with mental illness, including schizophrenia and suicidal behavior. T. gondii IgG antibody titers were measured via ELISA. The heritability of T. gondii IgG was estimated using a mixed model that included fixed effects for age and sex and random kinship effect. Of 2017 Old Order Amish participants, 1098 had positive titers (54.4%). The heritabil...
#1Javier Periz (Glas.: University of Glasgow)H-Index: 2
#2Mario Del Rosario (Glas.: University of Glasgow)H-Index: 1
Last. Markus Meissner M (Glas.: University of Glasgow)H-Index: 30
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The obligate intracellular parasite Toxoplasma gondii replicates in an unusual process, described as internal budding. Multiple dausghter parasites are formed sequentially within a single mother cell, requiring replication and distribution of essential organelles such as micronemes. These organelles are thought to be formed de novo in the developing daughter cells. Using dual labelling of a microneme protein MIC2 and super-resolution microscopy, we show that micronemes are recycled from the moth...
#1Zahady D. Vel谩squez (University of Giessen)H-Index: 1
#2Iv谩n Conejeros (University of Giessen)H-Index: 9
Last. Anja Taubert (University of Giessen)H-Index: 22
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Toxoplasma gondii is a zoonotic and intracellular parasite with fast proliferating properties leading to rapid host cell lysis. T. gondii modulates its host cell on numerous functional levels. T. gondii was previously reported to influence host cellular cell cycle and to dampen host cell division. By using primary endothelial host cells, we show for the first time that T. gondii tachyzoite infections led to increased host cell proliferation and to an enhanced number of multi-nucleated host cells...
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#1Tooran Nayeri Chegeni (Mazandaran University of Medical Sciences)H-Index: 2
#2Mehdi Sharif (Mazandaran University of Medical Sciences)H-Index: 17
Last. Ahmad Daryani (Mazandaran University of Medical Sciences)H-Index: 23
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Background Toxoplasma gondii (T. gondii) is an obligate intracellular opportunistic parasite that is the causative agent of toxoplasmosis. This parasite accounts for mental disorders; however, the relationship between T. gondii infection and depressive disorder is unclear. Regarding this, the present systematic review and meta-analysis was conducted to investigate the scientific evidence regarding the potential association between major depression disorder (MDD) and Toxoplasma infection. Methods...
#1David W. Donley (UW: University of Wyoming)H-Index: 1
#2Teal Jenkins (UW: University of Wyoming)
Last. Jonathan H. Fox (UW: University of Wyoming)H-Index: 11
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Toxoplasma gondii causes a prevalent neuroinvasive protozoal pathogen that in immune competent individuals results in latent infection characterized by intra-cellular parasite cysts in brain. Despite life-long infection, the role of latent toxoplasmosis on chronic neurodegenerative processes is poorly understood. Huntingtons disease (HD) is a progressive neurodegenerative disorder caused by a dominant CAG repeat expansion in the huntingtin gene (HTT) that results in the expression and accumulati...
#1Shiraz Tyebji (University of Melbourne)H-Index: 7
#2Simona Seizova (University of Melbourne)H-Index: 1
Last. Christopher J. Tonkin (University of Melbourne)H-Index: 27
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Abstract Toxoplasma gondii is an obligate intracellular parasite that resides, in a latent form, in the human central nervous system. Infection with Toxoplasma drastically alters the behaviour of rodents and is associated with the incidence of specific neuropsychiatric conditions in humans. But the question remains: how does this pervasive human pathogen alter behaviour of the mammalian host? This fundamental question is receiving increasing attention as it has far reaching public health implica...
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