Error-Prone Replication through UV Lesions by DNA Polymerase θ Protects against Skin Cancers
Abstract
Cancers from sun-exposed skin accumulate “driver” mutations, causally implicated in oncogenesis. Because errors incorporated during translesion synthesis (TLS) opposite UV lesions would generate these mutations, TLS mechanisms are presumed to underlie cancer development. To address the role of TLS in skin cancer formation, we determined which DNA polymerase is responsible for generating UV mutations, analyzed the relative contributions of...
Paper Details
Title
Error-Prone Replication through UV Lesions by DNA Polymerase θ Protects against Skin Cancers
Published Date
Mar 1, 2019
Journal
Volume
176
Issue
6
Pages
1295 - 1309.e15
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