Extraversion modulates cortisol responses to acute social stress in chronic major depression

Chronic Major Depressive Disorder (CMDD) is a common, disabling illness that is often complicated by high reactivity to social stress. To further elucidate the nature of this reactivity, the current study evaluated whether the personality dimensions of neuroticism and extraversion influenced cortisol responses to a social challenge in CMDD patients vs. controls. Fifty participants with CMDD and 58 healthy controls completed the Trier Social...